Article
Enhanced sensitivity to oxidant-induced micronucleus frequency in elderly individuals is not associated with glutathione S-transferase M1 (GSTM1) null genotype in lymphocytes.
Gerontology - 1 Jan 2000
Guven Gulgun S, Guven Mehmet, Onaran Ilhan, Tunckale Aydin, Hacihanefioglu Seniha, Ulutin Turgut
Abstract excerpt
BACKGROUND: A large number of studies have demonstrated that various kinds of DNA damage accumulate during aging and that oxidative stress possibly contributes to this process. Glutathione S-transferase M1 (GSTM1) can prevent their possible effects on DNA via detoxification of reactive substances that induced oxidative stress. OBJECTIVE: To investigate the relationship between GSTM1 polymorphism and DNA...
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