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Article

Are individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage?

Journal of toxicology and environmental health. Part A - 14 Jan 2000

Onaran I, Ozaydin A, Akbaş F, Gültepe M, Tunçkale A, Ulutin T

Abstract excerpt

Recent epidemiological studies proposed that glutathione S-transferase (GST) T1 null genotype was correlated with an increased susceptibility to diseases associated with oxidative stress, including cancer. A comparative study using erythrocytes from individuals with GSTT1 null genotype was carried out to determine how resistance to oxidative stress is affected by lack of this gene, and whether the GST status of a...

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Source

Identifiers

PMID: 10681096
DOI: 10.1080/009841000157041

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Are individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage?PMID 10681096Read ↗

The influence of GSTM1 null genotype on susceptibility to in vitro oxidative stress.Semantic proximity Read ↗

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Glutathione S-transferase A1, M1, P1 and T1 null or low-activity genotypes are associated with enhanced oxidative damage among haemodialysis patients.Semantic proximity Read ↗

Relation between glutathione S-transferase genes (GSTM1, GSTT1, and GSTP1) polymorphisms and clinical manifestations of sickle cell disease in Egyptian patients.Semantic proximity Read ↗

Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes.Semantic proximity Read ↗

Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.Semantic proximity Read ↗

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Influence of genetic polymorphisms of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) on hematological parameters.Semantic proximity Read ↗

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GSTT1 (rs4025935) null genotype is associated with increased risk of sickle cell disease in the populations of Tabuk-Northwestern region of Saudi Arabia.Semantic proximity Read ↗

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