Article
Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005
Zhao Haibo, Ross F Patrick, Teitelbaum Steven L
Abstract excerpt
Cell/matrix detachment is a general inducer of programmed cell death, an event mediated by loss of integrin/ligand association. Because alpha(v)beta3 is the major integrin expressed by the osteoclast, we asked whether its occupancy promotes survival of the resorptive cell. Thus, we generated wild-type preosteoclasts and placed them on selective matrix proteins. Consistent with the posture that alpha(v)beta3...
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