Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 1999

James I E, Lark M W, Zembryki D, Lee-Rykaczewski E V, Hwang S M, Tomaszek T A, Belfiore P, Gowen M

Abstract excerpt

A human in vitro resorption assay has been developed using osteoclastoma-derived osteoclasts and used to evaluate novel antiresorptive agents including antagonists of the alphavbeta3 integrin, and inhibitors of cathepsin K and the osteoclast ATPase. The potency of novel compounds in the in vitro resorption assay correlates with functional assays for each class of inhibitor: the human alphavbeta3-mediated cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Bone Resorption

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cathepsin K

Share to Cathepsins

Share to Cell Adhesion

Share to Cell Separation

Share to Freezing

Share to In Vitro Techniques

Source

Identifiers

PMID: 10469285
DOI: 10.1359/jbmr.1999.14.9.1562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.PMID 10469285Read ↗

Human osteoclast culture and phenotypic characterization.Semantic proximity Read ↗

Purification and characterization of fully functional human osteoclast precursors.Semantic proximity Read ↗

Arg-Gly-Asp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts.Semantic proximity Read ↗

Loss of mutually protective effects between osteoclasts and chondrocytes in damaged joints drives osteoclast-mediated cartilage degradation via matrix metalloproteinasesSemantic proximity Read ↗

Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL.Semantic proximity Read ↗

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants.Semantic proximity Read ↗

Production and characterization of new monoclonal antibodies to human osteoclasts.Semantic proximity Read ↗

Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality.Semantic proximity Read ↗

NVP-BHG712 against postmenopausal osteoporosis in mice by targeting Cathepsin KSemantic proximity Read ↗

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.Semantic proximity Read ↗

Time-lapse reveals that osteoclasts can move across the bone surface while resorbing.Semantic proximity Read ↗

Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.