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Article

H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts.

The Journal of biological chemistry - 14 Jun 2002

Tanaka Yoshiya, Nakayamada Shingo, Fujimoto Hiroko, Okada Yosuke, Umehara Hisanori, Kataoka Tohru, Minami Yasuhiro

Abstract excerpt

We have studied the relevance of H-Ras and its downstream effectors to osteoblast functions. 1) Purified human osteoblasts highly expressed integrins beta1, alpha4, alpha5, alpha6 and the activation epitope of beta1. However, these molecules were markedly down-regulated on osteoblasts transfected with expression vector encoding fully activated H-Ras(V12), H-Ras(V12)T35S, activating Raf-1/mitogen-activated protein...

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Identifiers

PMID: 11934900
DOI: 10.1074/jbc.M202238200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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