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Vitamin D receptor is essential for normal keratinocyte stem cell function

18 May 2007

Abstract excerpt

The major physiological role of the vitamin D receptor (VDR) is the maintenance of mineral ion homeostasis. Mutation of the VDR, in humans and mice, results in alopecia. Unlike the effects of the VDR on mineral ion homeostasis, the actions of the VDR that prevent alopecia are ligand-independent. Although absence of the VDR does not prevent the development of a keratinocyte stem cell niche in the bulge region of...

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PMID: 17517646
DOI: 10.1073/pnas.0702884104

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