Article
Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.
The Journal of investigative dermatology - 1 Jan 2002
Xie Zhongjion, Komuves László, Yu Qian-Chun, Elalieh Hashem, Ng Dean C, Leary Colin, Chang Sandra, Crumrine Debra, Yoshizawa Tatsuya, Kato Shigeaki, Bikle Daniel D
Abstract excerpt
The active vitamin D metabolite, 1,25-dihydroxyvitamin D, acting through the vitamin D receptor, regulates the expression of genes in a variety of vitamin D-responsive tissues, including the epidermis. To investigate the role of the vitamin D receptor in mediating epidermal differentiation, we examined the histomorphology and expression of differentiation markers in the epidermis of vitamin D receptor knockout...
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