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Article

Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

Science (New York, N.Y.) - 10 Dec 2004

Crabbe Laure, Verdun Ramiro E, Haggblom Candy I, Karlseder Jan

Abstract excerpt

Cells from Werner syndrome patients are characterized by slow growth rates, premature senescence, accelerated telomere shortening rates, and genome instability. The syndrome is caused by the loss of the RecQ helicase WRN, but the underlying molecular mechanism is unclear. Here we report that cells lacking WRN exhibit deletion of telomeres from single sister chromatids. Only telomeres replicated by lagging strand...

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Source

Identifiers

PMID: 15591207
DOI: 10.1126/science.1103619

Genes

WRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.PMID 15591207Read ↗

Telomere dysfunction as a cause of genomic instability in Werner syndromeSemantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structuresSemantic proximity Read ↗

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.Semantic proximity Read ↗

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.Semantic proximity Read ↗

Werner Protein Protects Nonproliferating Cells from Oxidative DNA DamageSemantic proximity Read ↗

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.Semantic proximity Read ↗

WRN Controls Formation of Extrachromosomal Telomeric Circles and Is Required for TRF2<sup>ΔB</sup>-Mediated Telomere ShorteningSemantic proximity Read ↗

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequencesSemantic proximity Read ↗

A role for WRN in telomere-based DNA damage responsesSemantic proximity Read ↗

Loss of Werner syndrome protein function promotes aberrant mitotic recombination.Semantic proximity Read ↗

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