Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway.

Abstract excerpt

BACKGROUND: Continuous exposure to light, even at relatively low intensities, leads to retinal damage and blindness in wild-type animals. However, the molecular mechanisms underlying constant-light-induced blindness are poorly understood. It has been presumed that the visual impairment resulting from long-term, continuous exposure to ambient light is a secondary consequence of the effects of light on retinal...

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