Article
A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila.
Neuron - 1 Oct 2000
Kiselev A, Socolich M, Vinós J, Hardy R W, Zuker C S, Ranganathan R
Abstract excerpt
Light-induced photoreceptor apoptosis occurs in many forms of inherited retinal degeneration resulting in blindness in both vertebrates and invertebrates. Though mutations in several photoreceptor signaling proteins have been implicated in triggering this process, the molecular events relating light activation of rhodopsin to photoreceptor death are yet unclear. Here, we uncover a pathway by which activation of...
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