Article
N-acetyl transferase 2 polymorphism and advanced stages of endometriosis in South Indian women.
Reproductive biomedicine online - 1 Nov 2004
Babu K Arvind, Rao K Lakshmi, Reddy N G Pavankumar, Kanakavalli M K, Zondervan Krina T, Deenadayal Mamata, Singh Amarpal, Shivaji S, Kennedy Stephen
Abstract excerpt
Aylamine-N-acetyl transferase is a phase II detoxification enzyme encoded by the gene NAT2. Single nucleotide polymorphism (SNP) changes from the wild type NAT2 *4 allele result in allelic variants *5, *6 and *7. Homozygotes for the NAT2 *4 wild type are fast acetylators; heterozygotes with one wild-type allele and a variant NAT2 *5, *6 or *7 allele have reduced enzyme activity and individuals with two variant...
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