Article
NAT2*5/*5 genotype (341T>C) is a potential risk factor for schistosomiasis-associated bladder cancer in Egyptians.
Therapeutic drug monitoring - 1 Jun 2005
El Desoky Ehab S, AbdelSalam Yasser M, Salama Ragaa H, El Akkad Magdy A, Atanasova Srebrena, von Ahsen Nicolas, Armstrong Victor W, Oellerich Michael
Abstract excerpt
Arylamine N-acetyl transferase (NAT2) displays extensive genetic polymorphisms that affect the rates of acetylation of drugs and genotoxic compounds such as amine carcinogens. To investigate whether the slow acetylator genotype is a risk factor for development of bladder cancer following schistosomal infection of the urinary tract, the authors determined the frequencies of 3 common polymorphisms in the NAT2 gene...
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