Article
IL-6 and IL-10 promoter gene polymorphisms do not associate with the susceptibility for multiple myeloma.
Immunology letters - 31 Jan 2005
Mazur Grzegorz, Bogunia-Kubik Katarzyna, Wróbel Tomasz, Karabon Lidia, Polak Małgorzata, Kuliczkowski Kazimierz, Lange Andrzej
Abstract excerpt
Multiple myeloma (MM) is a plasma cell malignancy characterised by bone marrow infiltration and the presence of a monoclonal protein in serum and/or urine. Interleukin-6 (IL-6) has been identified as one of the most important cytokines that contributes to myeloma cell survival and proliferation. Recent investigations suggest involvement of another cytokine, IL-10, in the activation of MM cells. The present study...
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