Article
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Feb 2007
Duch C R, Figueiredo M S, Ribas C, Almeida M S S, Colleoni G W B, Bordin J O
Abstract excerpt
It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels...
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