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Article

Interleukin-10 gene promoter polymorphisms in multiple myeloma

1 Jan 2001

Abstract excerpt

Multiple myeloma (MM) is a B-cell malignancy characterized by an accumulation of malignant plasma cells in the bone marrow. It is unclear whether genetic background could have an etiological impact on MM or influence the course of the disease. Interleukin-10 (IL-10) has been implicated in the growth and differentiation of normal B cells, and has also been shown to enhance the proliferation of MM cells. To address...

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PMID: 11307152
DOI: 10.1002/1097-0215(20010520)95:3<184::aid-ijc1031>3.0.co;2-v

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