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Article

Interleukin-6 gene-174 G/C promoter polymorphism and its association with clinical profile of patients with multiple myeloma.

Asia-Pacific journal of clinical oncology - 1 Oct 2017

Chakraborty Baidarbhi, Vishnoi Gaurav, Gowda Srinivas H, Goswami Binita

Abstract excerpt

AIM: In multiple myeloma (MM), the growth and survival of myeloma cells is controlled by interleukin-6 (IL-6), the plasma levels of which is controlled by a guanine/cytosine substitution occurring in position -174 of IL-6 gene promoter region. We studied the occurrence of IL-6-174 G/C polymorphism in patients of MM and correlated the presence of genotypes with serum IL-6 levels and tumor staging. METHODS: One...

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PMID: 25359504
DOI: 10.1111/ajco.12290

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