Article
[Association between tumor necrosis factor-beta polymorphisms and coronary heart disease in a Chinese population].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2004
Li Yan, Wang Ming, Zhang Ping-an, Chen Hui, Jiang Xue-jun, Huang Cong-xin
Abstract excerpt
OBJECTIVE: To investigate the association between tumor necrosis factor-beta (TNF-beta) gene polymorphisms and coronary heart disease (CHD). METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequence specific primer-PCR (PCR-SSP) were used for the detection of TNF-beta genotype in 210 patients with CHD and 186 healthy controls. The serum TNF-beta levels were measured by...
Topics
- Aged
- Asian People
- Coronary Disease
- Exons
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Introns
- Lymphotoxin-alpha
- Male
- Middle Aged
- Polymerase Chain Reaction