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Article

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma.

The Journal of cell biology - 6 Dec 2004

Thomas David M, Johnson Sandra A, Sims Natalie A, Trivett Melanie K, Slavin John L, Rubin Brian P, Waring Paul, McArthur Grant A, Walkley Carl R, Holloway Andrew J, Diyagama Dileepa, Grim Jonathon E, Clurman Bruce E, Bowtell David D L, Lee Jong-Seo, Gutierrez Gabriel M, Piscopo Denise M, Carty Shannon A, Hinds Philip W

Abstract excerpt

The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic expression of runx2 induces p27KIP1, thereby inhibiting the activity of S-phase cyclin complexes and leading to the...

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Identifiers

PMID: 15583032
DOI: 10.1083/jcb.200409187
PMCID: PMC2172443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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