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Article

Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p.

The Journal of cell biology - 6 Dec 2004

Wiederkehr Andreas, De Craene Johan-Owen, Ferro-Novick Susan, Novick Peter

Abstract excerpt

The exocyst is an octameric protein complex required to tether secretory vesicles to exocytic sites and to retain ER tubules at the apical tip of budded cells. Unlike the other five exocyst genes, SEC3, SEC5, and EXO70 are not essential for growth or secretion when either the upstream activator rab, Sec4p, or the downstream SNARE-binding component, Sec1p, are overproduced. Analysis of the suppressed sec3Delta,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15583030
DOI: 10.1083/jcb.200408001
PMCID: PMC2172455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p.PMID 15583030Read ↗

An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.Semantic proximity Read ↗

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The Physcomitrella patens exocyst subunit EXO70.3d has distinct roles in growth and development, and is essential for completion of the moss life cycle.Semantic proximity Read ↗

Exocyst Requirement for Endocytic Traffic Directed Toward the Apical and Basolateral Poles of Polarized MDCK CellsSemantic proximity Read ↗

Exo70p mediates the secretion of specific exocytic vesicles at early stages of the cell cycle for polarized cell growth.Semantic proximity Read ↗

The tomosyn homologue, Sro7, is a direct effector of the Rab GTPase, Sec4, in post-Golgi vesicle tethering.Semantic proximity Read ↗

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Dominant negative alleles of SEC10 reveal distinct domains involved in secretion and morphogenesis in yeast.Semantic proximity Read ↗

Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells.Semantic proximity Read ↗

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