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Article

Protein dynamics and electrostatics in the function of p-hydroxybenzoate hydroxylase.

Archives of biochemistry and biophysics - 1 Jan 2005

Entsch Barrie, Cole Lindsay J, Ballou David P

Abstract excerpt

para-Hydroxybenzoate hydroxylase is a flavoprotein monooxygenase that catalyzes a reaction in two parts: reduction of the enzyme cofactor, FAD, by NADPH in response to binding p-hydroxybenzoate to the enzyme, then oxidation of reduced FAD by oxygen to form a hydroperoxide, which oxygenates p-hydroxybenzoate to form 3,4-dihydroxybenzoate. These diverse reactions all occur within a single polypeptide and are...

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PMID: 15581585
DOI: 10.1016/j.abb.2004.09.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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