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Article

Phospholipase Cζ causes Ca2+ oscillations and parthenogenetic activation of human oocytes

1 Dec 2004

Abstract excerpt

At fertilization in mammals the sperm activates development of the oocyte by inducing a prolonged series of oscillations in the cytosolic free Ca2+ concentration. One theory of signal transduction at fertilization suggests that the sperm cause the Ca2+ oscillations by introducing a protein factor into the oocyte after gamete membrane fusion. We recently identified this sperm-specific protein as phospholipase...

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Identifiers

PMID: 15579586
DOI: 10.1530/rep.1.00484

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The cytosolic sperm factor that triggers Ca2+ oscillations and egg activation in mammals is a novel phospholipase C: PLCζSemantic proximity Read ↗

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