Article
A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Journal of the American Society of Nephrology : JASN - 1 Dec 2004
Piontek Klaus B, Huso David L, Grinberg Alexander, Liu Lijuan, Bedja Djahida, Zhao Haidan, Gabrielson Kathleen, Qian Feng, Mei Changlin, Westphal Heiner, Germino Gregory G
Abstract excerpt
Gene targeting has been used to create a variety of lines of mice with Pkd1 mutations that share many common features. Homozygous Pkd1 mutants invariably develop pancreatic and renal cysts if they survive to day 15.5 post coitum and die in either the fetal or the perinatal period. In contrast, mice with heterozygous mutations of Pkd1 are generally normal and have few if any renal cysts. These features have...
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