Article
Spermatogenesis from epiblast and primordial germ cells following transplantation into postnatal mouse testis.
Development (Cambridge, England) - 1 Jan 2005
Chuma Shinichiro, Kanatsu-Shinohara Mito, Inoue Kimiko, Ogonuki Narumi, Miki Hiromi, Toyokuni Shinya, Hosokawa Mihoko, Nakatsuji Norio, Ogura Atsuo, Shinohara Takashi
Abstract excerpt
Primordial germ cells (PGCs) are derived from a population of pluripotent epiblast cells in mice. However, little is known about when and how PGCs acquire the capacity to differentiate into functional germ cells, while keeping the potential to derive pluripotent embryonic germ cells and teratocarcinomas. In this investigation, we show that epiblast cells and PGCs can establish colonies of spermatogenesis after...
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