Article

Generation of spermatogonia from pluripotent stem cells in humans and non-human primates

2024-05-06

Abstract excerpt

Failures in germline development drive male infertility, but the lack of model systems that recapitulate human spermatogenesis hampers therapeutic development. Here, we have developed a system to differentiate human induced pluripotent stem cells (iPSCs) into primordial germ cell-like cells that self-organize within xenogeneic reconstituted testes (xrTestes) generated from mouse fetal testicular cells. Subsequent...

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Literature Corpus work: 44471764-ae6b-52cd-8d45-278c25fee90e
DOI: 10.1101/2024.05.03.592203

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