Article
Commitment of Fetal Male Germ Cells to Spermatogonial Stem Cells During Mouse Embryonic Development1
1 May 2004
Abstract excerpt
The continuous production of mammalian sperm is maintained by the proliferation and differentiation of spermatogonial stem cells that originate from primordial germ cells (PGCs) in the early embryo. Although spermatogonial stem cells arise from PGCs, it is not clear whether fetal male germ cells function as spermatogonial stem cells able to produce functional sperm. In the present study, we examined the timing...
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