Article
Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments.
The AAPS journal - 27 Nov 2017
Lauschke Volker M, Milani Lili, Ingelman-Sundberg Magnus
Abstract excerpt
Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to polymorphisms in genes encoding proteins involved in drug pharmacokinetics and pharmacodynamics or immunological responses. Pharmacogenetic research has identified a multitude of gene-drug response associations, which have resulted in genetically guided treatment and dosing decisions to yield a higher success rate of...
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