Article
Pharmacogenomics: historical perspective and current status.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Charlab Rosane, Zhang Lei
Abstract excerpt
Pharmacogenomics and its predecessor pharmacogenetics study the contribution of genetic factors to the interindividual variability in drug efficacy and safety. One of the major goals of pharmacogenomics is to tailor drugs to individuals based on their genetic makeup and molecular profile. From early findings in the 1950s uncovering inherited deficiencies in drug metabolism that explained drug-related adverse...
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