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Article

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.

Cellular signalling - 1 Feb 2015

Wolf Alexandra, Eulenfeld René, Bongartz Hannes, Hessenkemper Wiebke, Simister Philip C, Lievens Sam, Tavernier Jan, Feller Stephan M, Schaper Fred

Abstract excerpt

The timely orchestration of multiple signalling pathways is crucial for the integrity of an organism and therefore tightly controlled. Gab family proteins coordinate signal transduction at the plasma membrane (PM) by acting as docking platforms for signalling components involved in MAP kinase (MAPK), PI3 kinase (PI3K), phospholipase C (PLC) and Rho family GTPase signalling. The interaction with these components...

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Identifiers

PMID: 25460044
DOI: 10.1016/j.cellsig.2014.11.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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