Article
Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor.
The Biochemical journal - 1 Oct 2005
Meng Songshu, Chen Zhengming, Munoz-Antonia Teresita, Wu Jie
Abstract excerpt
Three members of Gab family docking proteins, Gab1, Gab2 and Gab3, have been identified in humans. Previous studies have found that the hepatocyte growth factor preferentially utilizes Gab1 for signalling, whereas Bcr-Abl selectively signals through Gab2. Gab1-SHP2 interaction has been shown to mediate ERK (extracellular-signal-regulated kinase) activation by EGF (epidermal growth factor). However, it was unclear...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Base Sequence
- COS Cells
- Cell Line, Tumor
- Cell Movement
- Chlorocebus aethiops
- Down-Regulation
- Enzyme Activation
- Epidermal Growth Factor
- Extracellular Signal-Regulated MAP Kinases
- Gene Expression Regulation, Enzymologic
- Gene Silencing