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Article

Serpinopathies and the conformational dementias.

Nature reviews. Genetics - 1 Oct 2002

Lomas David A, Carrell Robin W

Abstract excerpt

The serpin superfamily of serine proteinase inhibitors has a central role in controlling proteinases in many biological pathways in a wide range of species. The inhibitory function of the serpins involves a marked conformational transition, but this inherent molecular flexibility also renders the serpins susceptible to point mutations that result in aberrant intermolecular linkage and polymer formation. The...

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PMID: 12360234
DOI: 10.1038/nrg907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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