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Article

Shielding the front-strand beta 3 of the von Willebrand factor A1 domain inhibits its binding to platelet glycoprotein Ibalpha.

Blood - 15 Feb 2003

Bonnefoy Arnaud, Yamamoto Hiroshi, Thys Chantal, Kito Morikazu, Vermylen Jos, Hoylaerts Marc F

Abstract excerpt

Platelet adhesion to damaged vessel wall and shear-induced platelet aggregation necessitate binding of the von Willebrand factor (VWF) A1 domain to platelet GPIbalpha. Blocking this interaction represents a promising approach to the treatment of arterial thrombosis. Comparison of amino acid sequences of the VWF A1 domain in several species, expressing VWF recognized by the blocking monoclonal antibody AJvW-2,...

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Source

Identifiers

PMID: 12393553
DOI: 10.1182/blood-2002-06-1818

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shielding the front-strand beta 3 of the von Willebrand factor A1 domain inhibits its binding to platelet glycoprotein Ibalpha.PMID 12393553Read ↗

Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V.Semantic proximity Read ↗

Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations.Semantic proximity Read ↗

Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.Semantic proximity Read ↗

Platelet adhesion: a game of catch and release.Semantic proximity Read ↗

Type 2M von Willebrand disease: F606I and I662F mutations in the glycoprotein Ib binding domain selectively impair ristocetin- but not botrocetin-mediated binding of von Willebrand factor to platelets.Semantic proximity Read ↗

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.Semantic proximity Read ↗

Identification of the collagen-binding site of the von Willebrand factor A3-domain.Semantic proximity Read ↗

Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain.Semantic proximity Read ↗

Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib.Semantic proximity Read ↗

Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.Semantic proximity Read ↗

Structure and function of the von Willebrand factor A1 domain.Semantic proximity Read ↗

Threonine-145/methionine-145 variants of baculovirus produced recombinant ligand binding domain of GPIbalpha express HPA-2 epitopes and show equal binding of von Willebrand factor.Semantic proximity Read ↗

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