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Article

Self cloning in Micromonospora olivasterospora of fms genes for fortimicin A (astromicin) biosynthesis.

Molecular & general genetics : MGG - 1 Mar 1992

Dairi T, Ohta T, Hashimoto E, Hasegawa M

Abstract excerpt

We have cloned the seven genes that are responsible for biosynthesis of the antibiotic fortimicin A (FTM A) using a recently developed self-cloning system that employes the plasmid vector pMO116 for Micromonospora olivasterospora. Five chimeric plasmids that restored FTM A production in M. olivasterospora mutants blocked at different biosynthetic steps were isolated by shotgun cloning. Secondary transformation...

Topics

Aminoglycosides
Anti-Bacterial Agents
Cloning, Molecular
DNA, Bacterial
Genes, Bacterial
Genes, fms
Micromonospora
Mutation
Plasmids
Protoplasts
Restriction Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transformation, Genetic

Source

Identifiers

PMID: 1557033
DOI: 10.1007/BF00280005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1557033-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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