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Article

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.

Human molecular genetics - 1 May 2007

Zourlidou Alexandra, Gidalevitz Tali, Kristiansen Mark, Landles Christian, Woodman Ben, Wells Dominic J, Latchman David S, de Belleroche Jackie, Tabrizi Sarah J, Morimoto Richard I, Bates Gillian P

Abstract excerpt

Huntington's disease (HD) is caused by an expanded polyglutamine tract in the huntingtin protein. Mitochondrial dysfunction and free radical damage occur in both R6/2 mice and HD patient brains and might play a role in disease pathogenesis. In cell culture systems, heat-shock protein 27 (Hsp27), a small molecular chaperone, suppresses mutant huntingtin-induced reactive oxygen species formation and cell death. To...

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Identifiers

PMID: 17360721
DOI: 10.1093/hmg/ddm057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation.PMID 17360721Read ↗

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