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Article

A global approach combining proteome analysis and phenotypic screening with RNA interference yields novel apoptosis regulators.

Molecular & cellular proteomics : MCP - 1 Jan 2005

Machuy Nikolaus, Thiede Bernd, Rajalingam Krishnaraj, Dimmler Christiane, Thieck Oliver, Meyer Thomas F, Rudel Thomas

Abstract excerpt

Global approaches like proteome or transcriptome analyses have been performed extensively to identify candidate genes or proteins involved in biological and pathological processes. Here we describe the identification of proteins implicated in the regulation of apoptosis using proteome analysis and the functional validation of targets by RNA interference. A high-throughput platform for the validation of synthetic...

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Identifiers

PMID: 15567892
DOI: 10.1074/mcp.M400089-MCP200

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HDGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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