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Article

A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.

Journal of the American Society of Nephrology : JASN - 1 Nov 2015

Lee Ha Won, Khan Samia Q, Faridi Mohd Hafeez, Wei Changli, Tardi Nicholas J, Altintas Mehmet M, Elshabrawy Hatem A, Mangos Steve, Quick Kevin L, Sever Sanja, Reiser Jochen, Gupta Vineet

Abstract excerpt

Podocyte injury and loss mark an early step in the pathogenesis of various glomerular diseases, making these cells excellent targets for therapeutics. However, cell-based high-throughput screening assays for the rational development of podocyte-directed therapeutics are currently lacking. Here, we describe a novel high-content screening-based phenotypic assay that analyzes thousands of podocytes per assay...

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Source

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Identifiers

PMID: 25858967
DOI: 10.1681/ASN.2014090859
PMCID: PMC4625676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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