Article
Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population.
Schizophrenia research - 1 Feb 2005
Staddon Susan, Arranz Maria J, Mancama Dalu, Perez-Nievas Fernando, Arrizabalaga Iñaki, Anney Richard, Buckland Paul, Elkin Amanda, Osborne Sarah, Munro Janet, Mata Ignacio, Kerwin Robert W
Abstract excerpt
There are several lines of evidence implicating the dopamine D3 receptor in the pathophysiology of schizophrenia. The Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) has been the most extensively investigated DRD3 variant in connection with the disease but results have been inconclusive. Recent reports indicate that the Ser9Gly polymorphism is in linkage disequilibrium with other markers, but...
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