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Article

Adaptability costs in immune escape variants of vesicular stomatitis virus.

Virus research - 1 Jan 2005

Novella Isabel S, Gilbertson Dorothy L, Borrego Belen, Domingo Esteban, Holland John J

Abstract excerpt

We have used vesicular stomatitis virus (VSV) to determine the cost of antiserum resistance during escape from a polyclonal immune response. Replication of VSV in the presence of polyclonal antiserum resulted in the selection of antibody-escape mutants, as shown by increased fitness in the presence of antiserum and by increased resistance to neutralization. However, resistance came at a cost of overall fitness...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15567030
DOI: 10.1016/j.virusres.2004.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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