Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro and in vivo fitness of respiratory syncytial virus monoclonal antibody escape mutants.

Journal of virology - 1 Dec 2006

Zhao Xiaodong, Liu Enmei, Chen Fu-Ping, Sullender Wayne M

Abstract excerpt

Respiratory syncytial virus (RSV) is the only infectious disease for which a monoclonal antibody (MAb) is used in humans. Palivizumab (PZ) is a humanized murine MAb to the F protein of RSV. PZ-resistant viruses appear after in vitro and in vivo growth of RSV in the presence of PZ. Fitness for replication could be a determinant of the likelihood of dissemination of resistant viruses. We assessed the fitness of two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Cell Line
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Respiratory Syncytial Viruses

Share to Respiratory viral infections research

Share to RNA, Viral

Share to Sigmodontinae

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 17005645
DOI: 10.1128/JVI.01387-06
PMCID: PMC1642624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro and in vivo fitness of respiratory syncytial virus monoclonal antibody escape mutants.PMID 17005645Read ↗

In Vivo Selection of Respiratory Syncytial Viruses Resistant to PalivizumabSemantic proximity Read ↗

Variable resistance to palivizumab in cotton rats by respiratory syncytial virus mutants.Semantic proximity Read ↗

Respiratory syncytial virus escape mutant derived in vitro resists palivizumab prophylaxis in cotton rats.Semantic proximity Read ↗

Analysis of respiratory syncytial virus preclinical and clinical variants resistant to neutralization by monoclonal antibodies palivizumab and/or motavizumab.Semantic proximity Read ↗

Molecular Modeling Predicts Novel Antibody Escape Mutations in the Respiratory Syncytial Virus Fusion Glycoprotein.Semantic proximity Read ↗

Molecular modeling predicts novel antibody escape mutations in respiratory syncytial virus fusion glycoproteinSemantic proximity Read ↗

Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo.Semantic proximity Read ↗

Structural considerations in the fitness landscape of a virus.Semantic proximity Read ↗

Competitive Fitness of Influenza B Viruses Possessing E119A and H274Y Neuraminidase Inhibitor Resistance-Associated Substitutions in Ferrets.Semantic proximity Read ↗

Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.Semantic proximity Read ↗

Development of motavizumab, an ultra-potent antibody for the prevention of respiratory syncytial virus infection in the upper and lower respiratory tract.Semantic proximity Read ↗

Quantitative evaluation of viral fitness due to a single nucleotide polymorphism in the Marek's disease virus UL41 gene via an in vitro competition assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.