Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.

Current stem cell research & therapy - 1 Jan 2015

Choi Hyowon, Johnson Zariel I, Risbud Makarand V

Abstract excerpt

Intervertebral disc (IVD) degeneration and associated low back pain (LBP) remains a major burden to our society without significant improvements in treatment strategies or patient's quality of life. While the recent cell-transplantation studies for treatment of degenerative disc disease have shown promising results, to better gauge the success and functional outcomes of these therapies, it is crucial to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell- and Tissue-Based Therapy
Share to IVD gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LBP gene

Share to Intervertebral Disc

Share to Intervertebral Disc Degeneration

Share to Phenotype

Share to Stem Cell Transplantation

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 25584906
DOI: 10.2174/1574888x10666150113112149
PMCID: PMC4437858

Genes

IVD
LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding nucleus pulposus cell phenotype: a prerequisite for stem cell based therapies to treat intervertebral disc degeneration.PMID 25584906Read ↗

Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies.Semantic proximity Read ↗

Identification of novel nucleus pulposus markersSemantic proximity Read ↗

Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting.Semantic proximity Read ↗

An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration.Semantic proximity Read ↗

Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degenerationSemantic proximity Read ↗

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation.Semantic proximity Read ↗

Diversity of intervertebral disc cells: phenotype and function.Semantic proximity Read ↗

Differentiation of Pluripotent Stem Cells into Nucleus Pulposus Progenitor Cells for Intervertebral Disc RegenerationSemantic proximity Read ↗

The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?Semantic proximity Read ↗

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?Semantic proximity Read ↗

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc RegenerationSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals the Difference in Human Normal and Degenerative Nucleus Pulposus Tissue Profiles and Cellular InteractionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.