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Article

Effects of hypoxias and scaffold architecture on rabbit mesenchymal stem cell differentiation towards a nucleus pulposus-like phenotype.

Biomaterials - 1 Nov 2011

Feng Ganjun, Jin Xiaobing, Hu Jiang, Ma Haiyun, Gupte Melanie J, Liu Hao, Ma Peter X

Abstract excerpt

Nucleus pulposus grafts are needed for patients requiring replacement of their degenerated intervertebral discs. Bone marrow-derived mesenchymal stem cells (MSCs) are a potential autologous stem cell source for the nucleus pulposus regeneration. One of the key issues of constructing functional nucleus pulposus using MSCs, however, is to differentiate MSCs into nucleus pulposus phenotype in vitro and to maintain...

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Identifiers

PMID: 21839506
DOI: 10.1016/j.biomaterials.2011.07.049
PMCID: PMC3163834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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