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Article

Physiological and pathological impact of AQP1 knockout in mice

25 Apr 2019

Abstract excerpt

Aquaporin 1 (AQP1) is a glycoprotein responsible for water passive transport quickly across biological membrane. Here, we reviewed the structural and functional impacts of AQP1 knockout (AQP1-KO) in animal or cell culture models. AQP1 gene deletion can cause a large number of abnormalities including the disturbance in epithelial fluid secretion, polyhydramnios, deficiency of urinary concentrating function, and...

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PMID: 31023968
DOI: 10.1042/bsr20182303

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