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Article

Crystal structure of the complex of plasminogen activator inhibitor 2 with a peptide mimicking the reactive center loop.

The Journal of biological chemistry - 16 Nov 2001

Jankova L, Harrop S J, Saunders D N, Andrews J L, Bertram K C, Gould A R, Baker M S, Curmi P M

Abstract excerpt

The structure of the serpin, plasminogen activator inhibitor type-2 (PAI-2), in a complex with a peptide mimicking its reactive center loop (RCL) has been determined at 1.6-A resolution. The structure shows the relaxed state serpin structure with a prominent six-stranded beta-sheet. Clear electron density is seen for all residues in the peptide. The P1 residue of the peptide binds to a well defined pocket at the...

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Identifiers

PMID: 11546761
DOI: 10.1074/jbc.M103021200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Crystal structure of the complex of plasminogen activator inhibitor 2 with a peptide mimicking the reactive center loop.PMID 11546761Read ↗

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