Article
A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Feb 2005
Ewald H, Wikman F P, Teruel B M, Buttenschön H N, Torralba M, Als T D, El Daoud A, Flint T J, Jorgensen T H, Blanco L, Kruse T A, Orntoft T F, Mors O
Abstract excerpt
Homozygosity mapping is a very powerful method for finding rare recessive disease genes in monogenic disorders and may also be useful for locating risk genes in complex disorders, late onset disorders where parents often are not available, and for rare phenotypic subgroups. In the present study, homozygosity mapping was applied to 24 persons with bipolar disorder from 22 inbred families. The families were...
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