Article
Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Delta 32 deletion.
Journal of vascular surgery - 1 Nov 2004
Ghilardi Giorgio, Biondi Maria Luisa, Battaglioli Lodovica, Zambon Antonella, Guagnellini Emma, Scorza Roberto
Abstract excerpt
OBJECTIVE: Inflammation is involved in the pathogenesis of atherosclerosis and abdominal aortic aneurysm (AAA), and chemokines are mediators of the inflammatory process. The homozygous Delta 32 deletion mutation of the gene of the chemokine receptor CCR5 is a cause of its lack in inflammatory cells. The purpose of this study was to investigate the relationship between CCR5 Delta 32 deletion mutation and AAA,...
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