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Article

Severity of human african trypanosomiasis in East Africa is associated with geographic location, parasite genotype, and host inflammatory cytokine response profile.

Infection and immunity - 1 Dec 2004

MacLean Lorna, Chisi John E, Odiit Martin, Gibson Wendy C, Ferris Vanessa, Picozzi Kim, Sternberg Jeremy M

Abstract excerpt

The mechanisms underlying virulence in human African trypanosomiasis are poorly understood, although studies with experimental mice suggest that unregulated host inflammatory responses are associated with disease severity. We identified two trypanosomiasis foci with dramatically different disease virulence profiles. In Uganda, infections followed an acute profile with rapid progression to the late stage...

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Identifiers

PMID: 15557627
DOI: 10.1128/IAI.72.12.7040-7044.2004
PMCID: PMC529158

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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