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Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology.

PLoS neglected tropical diseases - 1 May 2024

Nambala Peter, Noyes Harry, Namulondo Joyce, Nyangiri Oscar, Alibu Vincent Pius, Nerima Barbara, MacLeod Annette, Matovu Enock, Musaya Janelisa, Mulindwa Julius

Abstract excerpt

BACKGROUND: Sleeping sickness caused by Trypanosoma brucei rhodesiense is a fatal disease and endemic in Southern and Eastern Africa. There is an urgent need to develop novel diagnostic and control tools to achieve elimination of rhodesiense sleeping sickness which might be achieved through a better understanding of trypanosome gene expression and genetics using endemic isolates. Here, we describe transcriptome...

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PMID: 38701067
DOI: 10.1371/journal.pntd.0011516
PMCID: PMC11095692

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