Article
The major histocompatibility complex haplotype affects T-cell recognition of mycobacterial antigens but not resistance to Mycobacterium tuberculosis in C3H mice.
Infection and immunity - 1 Dec 2004
Kamath Arati B, Alt Jennifer, Debbabi Hajer, Taylor Chad, Behar Samuel M
Abstract excerpt
Both innate and adaptive immunity play an important role in host resistance to Mycobacterium tuberculosis infection. Although several studies have suggested that the major histocompatibility complex (MHC) haplotype affects susceptibility to infection, it remains unclear whether the modulation of T-cell immunity by the MHC locus determines the host's susceptibility to tuberculosis. To determine whether allelic...
Topics
- Animals
- Antigens, Bacterial
- Female
- Genetic Predisposition to Disease
- H-2 Antigens
- Haplotypes
- Immunologic Memory
- Interferon-gamma
- Lymphocyte Activation
- Major Histocompatibility Complex
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL