Article
Resistance to chlamydial lung infection is dependent on major histocompatibility complex as well as non-major histocompatibility complex determinants.
Immunology - 1 Dec 2005
Qiu Hongyu, Wang Shuhe, Yang Jie, Fan Yijun, Joyee Antony George, Han Xiaobing, Jiao Lei, Yang Xi
Abstract excerpt
Our previous work has shown that C3H/HeN and C57BL/6 mice have differential susceptibility to Chlamydia trachomatis mouse pneumonitis (C. muridarum) lung infection. C3H/HeN (H-2(k)) mice were found to be highly susceptible to C. muridarum infection with higher mortality and more severe morbidity compared to C57BL/6 (H-2(b)) mice. To examine the role of major histocompatibility complex (MHC) genes on host...
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