Article
Capacity of murine T cells to retain long-term responsiveness to mycobacterial antigens is controlled by the H-2 complex.
Clinical and experimental immunology - 1 Feb 1998
Pichugin A V, Khaidukov S V, Moroz A M, Apt A S
Abstract excerpt
It is firmly established that the allelic composition of the H-2 complex has a prominent impact on the course of tuberculosis (TB) infection in mice, including granuloma formation, mycobacterial spread in the lungs, and the dynamics of mortality. Although intuitively obvious, the role of long-ter...
Topics
- Animals
- Antigens, Bacterial
- CD4-CD8 Ratio
- Cell Survival
- Cytokines
- Epitopes, T-Lymphocyte
- Genotype
- H-2 Antigens
- Immunologic Memory
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mycobacterium tuberculosis
- Phenotype
- T-Lymphocytes
- Tuberculosis