Article
Mouse Model for Sporadic Mutation of Target Alleles to Understand Tumor Initiation and Progression and Stem Cell Dynamics.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020
Nguyen Theresa N, Manalo Elise C, Kawashima Taryn E, Fischer Jared M
Abstract excerpt
Recent evidence has shown that many different tissues accumulate mutations even though the tissue is phenotypically normal. Therefore, generating mouse models for visualizing the tissue level effects that happen after oncogenic mutation in a single, isolated cell are critical for understanding tumor initiation and the role of competition in stem cell dynamics. Most mouse models have oncogenic mutations at the...
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